The complexity of biological system urgently demands computational models which can produce new understanding and new medicine. Keeping in view Khwarizmi Science society and Journal Club at IRCBM, COMSATS jointly presents a seminar on agent based modeling approach in Investigating Multiscale Tumorigenesis in the Warburg Effect.
Early stage tumorigenesis includes the formation of glycolytic cells in the tissue. However, the precise multi-scale processes underlying this transformation of healthy epithelial cells into tumorigenic glycolytic phenotypes, continues to be a matter of debate. In this work, we investigate this cellular transformation by using an agent based modeling approach and decode a multifactorial mechanism which upon triggering may lead to the onset of tumorigenesis